Prostate cancer is recognized as one of the major medical problems faced by the male population. In Europe, an estimated 2.6 million new cases of cancer are diagnosed each year. Prostate cancer survivors face serious long-term side effects, thus improved treatment pathways enabled by AI, such as those targeted by INCISIVE, are urgently required.
The enormous progress in survival rates, and the fact that long-term prostate cancer survivors are at increased risk for comorbidities, suggests the time is right for a stronger focus on patient outcomes, optimized care pathways and precision medicine to accelerate personalized medicine approvals, reduce long-term care requirements and address influences on patient outcomes.
Multiparametric magnetic resonance imaging (mpMRI) is the technique of choice in the diagnosis of prostate cancer, allowing the location and staging of prostate cancer. Several studies have demonstrated that mpMRI can improve the sensitivity and specificity of prostate cancer detection and its use have increased the detection of higher-grade cancer, however, around 10-15% of clinically significant tumors cannot be detected. Relapsing level of prostate-specific antigen (PSA) after surgery treatment is often the first sign of recurrence. However, PSA level recurrence does not enable accurate differentiation of locally recurrent tumor from metastatic disease.
Several studies have demonstrated that mpMRI can improve the sensitivity and specificity of prostate cancer detection and its use have increased the detection of higher-grade cancer, however, around 10-15% of clinically significant tumors cannot be detected.
Conventional imaging, including CT and bone scan, has long been the standard of care but have limited sensitivity in depicting early local recurrence or metastatic disease. Currently, the use of MRI after surgical treatment to detect recurrences and progression is increasing since it has shown to be more sensitive in detecting locally recurrent tumor in the prostatectomy bed, as well as in recurrence in a prostate gland that has been treated with radiation therapy or thermal ablation.
The challenges addressed in INCISIVE are the following: